Gene transfer produces angiogenesis

BMJ 1996; 313 doi: (Published 17 August 1996) Cite this as: BMJ 1996;313:384

Doctors in the United States have succeeded in using gene therapy to create new blood vessels in patients with severe peripheral vascular disease. Reporting in the Lancet (1996;348:370-4), the research team, from Tufts University School of Medicine, Boston, said that the gene transfer caused the blood flow to the ischaemic leg of a 70 year old woman to increase by over 80%. And after four weeks, growth of a network of collateral blood vessels was clearly visible in an angiogram and microscopically.

Lead researcher Dr Jeffrey Isner, professor of medicine at Tufts University and head of cardiovascular research at the St Elizabeth Medical Center, Boston, said that the results could have major implications for patients who have …

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