Genetic liability to osteoarthritis may be greater in women than men

BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7051.232 (Published 27 July 1996) Cite this as: BMJ 1996;313:232
  1. Jaakko Kaprio,
  2. Urho M Kujala,
  3. Leena Peltonen,
  4. Markku Koskenvuo
  1. Senior research fellow Department of Public Health, University of Helsinki, FIN-00290 Helsinki, Finland
  2. Chief physician Unit for Sports and Exercise Medicine, Institute of Biomedicine, University of Helsinki
  3. Professor Department of Human Molecular Genetics, National Public Health Institute, Helsinki
  4. Professor Department of Public Health, University of Turku, Turku, Finland

    EDITOR,—Tim D Spector and colleagues report a study of genetic influences on osteoarthritis in monozygotic and dizygotic female twins.1 They conclude that their results show a clear genetic effect for radiographic osteoarthritis of the hand and knee in women (ranging from 39% to 65%) independent of known environmental or demographic confounders. In his commentary on the paper John Hopper states that these figures must be considered to be an upper bound of the genetic influence.1

    In a questionnaire sent to the Finnish twin cohort …

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