Endothelium dependent arterial dilatation in non-insulin dependent diabetes

BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7049.110 (Published 13 July 1996) Cite this as: BMJ 1996;313:110

Authors' finding is not new

  1. G Dennis Johnston,
  2. Ailish M Nugent,
  3. Randal J Hayes,
  4. Gary E Mcveigh
  1. Reader in clinical pharmacology Department of Therapeutics and Pharmacology, Queen's University of Belfast, Belfast BT9 7BL
  2. Registrar in general medicine Professor of medicine Department of Medicine, Belfast City Hospital Trust, Belfast BT9 7AB
  3. Assistant professor of medicine Department of Medicine, University of Minnesota, Box 741, 420 Delaware Street SE, Minneapolis, MN 55455, USA

    EDITOR,—In 1992 we published a study showing that endothelium dependent and endothelium independent vasodilatation was impaired in 29 patients with non-insulin dependent diabetes compared with 21 controls matched for age and sex.1 The vasodilator responses to acetylcholine and glyceryl trinitrate were impaired, as was arterial compliance, which was studied by wave-form analysis.2 We were unable to show differences between the two groups in the responses of forearm blood flow during reactive hyperaemia.1

    Jonathan Goodfellow and colleagues report similar work but used different methods …

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