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Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study

BMJ 1996; 312 doi: (Published 25 May 1996) Cite this as: BMJ 1996;312:1339
  1. Muhammad B Yunus, professor of medicine, section of rheumatologya,
  2. Jean C Aldag, associate professor of preventive medicine in medicinea
  1. a Department of Medicine, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
  1. Correspondence to: Professor Yunus.
  • Accepted 18 December 1995

Restless legs syndrome is characterised by an unpleasant, difficult-to-describe sensation in the legs that produces an invariable urge to move them frequently.1 2 3 This symptom typically occurs at rest or before sleep and is alleviated by activity.1 2 3 Restless legs syndrome may occur without or with an associated condition, such as rheumatoid arthritis.1 3 We investigated the prevalence of restless legs syndrome and of leg cramps in patients with fibromyalgia syndrome, a common condition with widespread musculoskeletal aching and tender points,2 4 and in controls.

Subjects, methods, and results

One hundred and thirty five consecutive new female patients referred with primary fibromyalgia, 54 women with rheumatoid arthritis without concomitant fibromyalgia, and 87 healthy, pain free women acting as controls were studied at our outpatient rheumatology clinic. All patients with fibromyalgia …

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