Authors' reply

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7041.1299a (Published 18 May 1996) Cite this as: BMJ 1996;312:1299
  1. P H A Steegmans,
  2. D E Grobbee,
  3. D Fekkes,
  4. A W Hoes
  1. Research associate Professor Department of Epidemiology and Biostatistics, Erasmus University Medical School, PO Box 1738, 3000 DR Rotterdam, Netherlands
  2. Assistant professor Section Pathophysiology of Behaviour, Erasmus University Medical School
  3. Assistant professor Department of General Practice, Erasmus University Medical School

    EDITOR,—Hanno Pijl and colleagues suggest that the higher alcohol intake in our reference group could explain the higher plasma serotonin concentration in the group. The study they refer to, however, is an in vitro study. Although platelet serotonin concentrations are generally decreased in alcoholic subjects,1 2 the effects on plasma serotonin concentrations are unknown. In one study platelet uptake of serotonin was increased in alcoholic subjects, without modifications of the paroxetine binding site.3 The results are therefore equivocal. Importantly, adjustment for use of alcohol did …

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