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…but “quasirandom allocation” of treatment was reported in 1930

BMJ 1996; 312 doi: (Published 18 May 1996) Cite this as: BMJ 1996;312:1298
  1. Mike Clarke
  1. Sydney Breast Cancer Institute visiting fellow National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW 2006, Australia

    EDITOR,—P D'Arcy Hart rightly points out1 that the history of controlled clinical trials predates the publications in 1948 of the Medical Research Council's trial of streptomycin2 and the Dutch trial of paludrine in malaria.3 In their study Carla van der Wijden and John A Overbeke do not seem to have searched issues of Nederlands Tijdschrift voor Geneeskunde before that year,4 and, if that is so, it is not surprising that they did not find any randomised trials. …

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