Association may be due to imbalance in ratio of adrenal androgens to glucocorticoid

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7034.845a (Published 30 March 1996) Cite this as: BMJ 1996;312:845
  1. M J Reed,
  2. M W Ghilchik
  1. Professor of steroid biochemistry Imperial College of Science, Technology and Medicine, London W2 1PG
  2. Consultant surgeon Breast Unit, St Mary's Hospital, London W2 1NY

    EDITOR,—C C Chen and colleagues report convincing evidence for an association between life stress and breast cancer but suggest that it would be a formidable task to account for this association with a biologically plausible mechanism.1 Recent studies carried out by my group into the regulation of the synthesis of oestrogen in breast tumours from postmenopausal women have indicated a possible mechanism by which adverse life events could enhance this synthesis.

    Oestrogens are the …

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