Tuberculosis as a predictor of survival in AIDS

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7033.776a (Published 23 March 1996) Cite this as: BMJ 1996;312:776

Study had several flaws

  1. William C Holmes,
  2. Elly T Katabira
  1. National Research Service Award fellow Clinical epidemiology fellow Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA

    EDITOR,—Several problems with Thomas V Perneger and colleagues' paper on whether the onset of tuberculosis in AIDS predicts shorter survival challenge their findings.1 Firstly, the title is misleading. The study evaluated people diagnosed as having AIDS during a 13 year period, whereas the title implies a 13 year follow up. This potential misinformation should be clarified by the reporting of median follow up in the text. Mean follow up, which the authors report, can be heavily skewed by a few subjects with lengthy follow up. …

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