Authors' reply

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7030.580b (Published 02 March 1996) Cite this as: BMJ 1996;312:580
  1. Nadia Badawi,
  2. Louisa M Alessandri,
  3. Jennifer J Kurinczuk,
  4. Paul R Burton,
  5. Fiona J Stanley,
  6. Patrick J Pemberton
  1. Paediatric research fellow Research officer Epidemiologist Senior biostatistician Director TVW Telethon Research Institute for Child Health Research, PO Box 855, West Perth 6872, Western Australia, Australia
  2. Director Department of Neonatology, Princess Margaret Hospital for Children, Subiaco 6008, Western Australia

    EDITOR,—We agree with J Girling and M de Swiet that our pilot study did not establish a causal link between use of thyroxine and subsequent neonatal encephalopathy. The study was intended to generate a hypothesis, which we are testing in a further study. Preliminary data from this study (excluding data from the pilot study) show that the range of thyroid disease in the women includes Graves' disease, primary hypothyroidism, and hypothyroidism after medical or surgical treatment. The unadjusted odds ratio is 4.8 (95% confidence interval 1.22 to 18.8), which suggests …

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