Early controlled clinical trials

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7027.378c (Published 10 February 1996) Cite this as: BMJ 1996;312:378
  1. P D'Arcy Harta
  1. Former director, MRC Tuberculosis Research Unit National Institute for Medical Research, London NW7 1AA

    EDITOR,—Carla L van der Wijden and John A Overbeke state that the publication of randomised clinical trials started in the late 1940s.1 They cite a Dutch trial of paludrine in malaria and the Medical Research Council's first trial of streptomycin in pulmonary tuberculosis, carried out by the council's Tuberculosis Research Unit; both trials were reported in 1948. I wish to question this priority, favoured though …

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