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Surgical bleeding and calcium antagonists

BMJ 1996; 312 doi: (Published 03 February 1996) Cite this as: BMJ 1996;312:313
  1. Markelu Hynynen,
  2. Anne Kuitunen,
  3. Markku Salmenpera
  1. Associate professor Staff anaesthesiologist Associate professor Department of Anaesthesia, Helsinki University Hospital, FIN-00290 Helsinki, Finland

    EDITOR,—L E Wagenknecht and colleagues have reported the use of nimodipine, a dihydropyridine calcium antagonist, in 149 patients undergoing replacement of a cardiac valve.1 In a randomised, placebo controlled, double blind clinical trial nimodipine (30 mg started 12 hours before surgery and given four times a day for five days) increased major bleeding. Although patients scheduled for cardiac surgery commonly receive calcium antagonists until the operation as part of their long term cardiovascular treatment,2 Wagenknecht and colleagues' finding raises the possibility that …

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