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Environment and genetic link found

BMJ 1996; 312 doi: (Published 03 February 1996) Cite this as: BMJ 1996;312:270
  1. Tessa Richards

    The first association between a specific genotype and an increased risk of coronary artery disease is reported in an Australian study published in Nature Medicine (1996;2:415). The genotype is at the endothelial nitric oxide synthetase locus. The study found that patients who were homozygous for the rare allele (version of the gene), designated 4a, who either smoked or were ex-smokers had more severe coronary artery disease than those who had never smoked. The data suggest a possible interaction between genetic and environmental factors that increases the risk of coronary …

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