Effect of intensive treatment in insulin dependent diabetes mellitus with microalbuminuria

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7025.253a (Published 27 January 1996) Cite this as: BMJ 1996;312:253

Sample size was too small

  1. Nish Chaturvedi,
  2. John H Fuller
  1. Research fellow Reader in epidemiology EURODIAB, Department of Epidemiology and Public Health, University College, London WC1E 6BT

    EDITOR,—The Microalbuminuria Collaborative Study Group concludes that intensive glycaemic control has no effect on the progression of albuminuria in people with insulin dependent diabetes mellitus who already have microalbuminuria.1 These conclusions have important implications for the care of diabetic patients and should not go unchallenged.

    The main problem with this study, as the authors admit, is the sample size. If we assume that 21% of patients with microalbuminuria will progress to overt albuminuria, as shown in this and other studies, and we wish to …

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