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Early evidence of scleroderma

BMJ 1995; 311 doi: (Published 23 December 1995) Cite this as: BMJ 1995;311:1714
  1. Jan Dequeker, professora,
  2. Ludo Vanopdenbosch, research medical studenta,
  3. Antonio Castillo Ojugas
  1. aArthritis and Metabolic Bone Disease Research Unit, K U Leuven, U Z Pellenberg, B-3212 pellenberg, Belgium
  1. Correspondence to: Professor Dequeker.Rheumatology Unit, Hospital “12 de Octubre,” Madrid, Spain Antonia Castillo Ojugas, professor.

    The painting of Archangel Raphael and Bishop Francisco Domonte by Murillo (1680) is in the Pushkin Museum of Fine Arts in Moscow (fig 1). The portrait of the bishop in the lower right hand corner shows several characteristic features of scleroderma. The most striking alterations of the skin are the numerous small telangiectases on the face, lips, and hands and the tight skin around the nose, cheeks, and forehead (fig2)). At the finger the transverse skin plicae of the knuckles are not visible and the …

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