Vitamin D receptor genotype and bone mineral density

BMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.7009.874a (Published 30 September 1995) Cite this as: BMJ 1995;311:874
  1. Munro Peacock,
  2. Frank G Hustmyer,
  3. Siu Hui,
  4. C Conrad Johnston,
  5. Joe Christian
  1. Director Postdoctoral fellow General Clinical Research Center, 550 N University Boulevard, 5595 Indianapolis, IN 46202, USA
  2. Professor of medicine Regenstrief Health Center, 1001 W 10th Street, Indianapolis, IN 46202
  3. Professor of medicine 545 N Barnhill Drive, 421 Indianapolis, IN 46202
  4. Director Medical and Molecular Genetics, 975 W Walnut Street, 135 Indianapolis, IN 46202

    Evidence conflicts on link

    EDITOR,--Two linkage studies of vitamin D receptor genotype and bone mineral density have reported different results. In Australian twins the vitamin D receptor gene was in strong linkage with bone mineral density.1 In contrast, in American twins we found no evidence of linkage of the vitamin D receptor gene with bone mineral density.2 We were therefore interested in the study in British twins to see if it sheds light on these contrasting findings.3 Unfortunately, it does not.

    Despite the fact that there were no significant (P<0.05) differences between dizygotic intraclass correlations in twins concordant and discordant for the vitamin D receptor gene …

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