Pregnancy in women with cystic fibrosis

BMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.7009.822 (Published 30 September 1995) Cite this as: BMJ 1995;311:822
  1. F P Edenborough,
  2. D E Stableforth,
  3. W E Mackenzie
  1. Cystic fibrosis clinical fellow Consultant in respiratory medicine Adult Cystic Fibrosis Unit, Birmingham Heartlands Hospital, Birmingham B9 5SS
  2. Consultant obstetrician Princess of Wales Maternity Unit, Birmingham Heartlands Hospital, Birmingham B9 5SS

    Outcomes for mother and baby have much improved

    The first successful pregnancy in a woman with cystic fibrosis was reported in 1960--at a time when the median survival of children with the disease was less than 10 years.1 The patient died six weeks after delivery, and the authors concluded that “cystic fibrosis is seriously complicated by pregnancy.” Since then reports have documented a gradual change from high fetal loss and maternal death due to cor pulmonale and respiratory failure to a good chance of a successful full term delivery of healthy infants to mothers whose overall health may be little changed.2 3 4 5 Sadly, this outcome is not available to patients whose health is poor or to those few women who have been sterilised or warned not to conceive.

    How, then, in the late 1990s should doctors approach the issues …

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