Megatrials are subordinate to medical science

BMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.6999.257b (Published 22 July 1995) Cite this as: BMJ 1995;311:257
  1. Bruce G Charlton
  1. Lecturer Department of Epidemiology and Public Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH

    EDITOR,--Evidence based medicine started life as a flawed but marvellously refreshing approach to clinical practice and continuing education.1 Unfortunately, it has recently been taken up by politicians and managers and is rrently being packaged and promoted as a panacea, at the expense of medical science.

    The main defining feature of evidence based medicine is its assertion that randomised controlled trials, especially “megatrials,” should serve …

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