Variability among studies should be investigated

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6994.1604a (Published 17 June 1995) Cite this as: BMJ 1995;310:1604
  1. A Perry,
  2. R Persaud
  1. Senior house officer in psychiatry Consultant psychiatrist Westways, West Croydon, Surrey CR9 2RR

    EDITOR,—Matthias Egger and George Davey Smith explain how pooling of smaller studies can turn out to be misleading after the subsequent publication of larger trials and suggest that meta-analyses of small trials should now be distrusted, even if their combined effect reaches significance.1 Yet they also point out that evidence from megatrials will continue to be unavailable for most medical interventions, and hence meta-analyses of smaller trials remain the only …

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