Vitamin C and vascular disease

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6994.1548 (Published 17 June 1995) Cite this as: BMJ 1995;310:1548
  1. Christopher J Bulpitt
  1. Professor of geriatric medicine Division of Geriatric Medicine, Royal Postgraduate Medical School Hammersmith Hospital, London W12 0HS

    Be cautious about the association until large randomised trials havebeen done

    Stroke, coronary heart disease, and peripheral vascular disease have many risk factors, or risk indicators, in common, yet some factors are more important for one vascular bed than another. Cigarette smoking is a stronger determinant of peripheral vascular disease than of stroke, high blood pressure is more important for stroke than for coronary artery disease, and a high serum cholesterol concentration has a greater effect on coronary heart disease than on stroke. Other factors may be equally important in all these conditions, and Meade has argued that this is the case for a high plasma concentration of fibrinogen.1 In this week's BMJ Khaw and Woodhouse examine the association between a low vitamin C concentration in elderly people and a high fibrinogen concentration (p 1559)2 and Gale and colleagues report cardiovascular mortality according to vitamin C intake (p 1563).3

    Khaw and Woodhouse followed up 96 men and women every two months for over a year.2 They …

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