Intended for healthcare professionals


Screening sperm donors for cystic fibrosis

BMJ 1995; 310 doi: (Published 10 June 1995) Cite this as: BMJ 1995;310:1533
  1. Ian Findlay,
  2. Howard Cuckle,
  3. Richard J Lilford,
  4. Anthony J Rutherford,
  5. Philip Quirke,
  6. Steven Lui
  1. Research fellow Professor of reproductive epidemiology Chairman of epidemiology and health services research Institute of Epidemiology and Health Services Research, University of Leeds, Leeds LS2 9LN
  2. Director, assisted conception unit Head of histopathology and molecular pathology Leeds General Infirmary, Leeds, LS1 3EX
  3. Senior embryologist IVF Unit, Princess Royal Hospital, Hull HU8 9HE

    EDITOR,—Cystic fibrosis is the most common serious autosomal recessive condition in white populations, affecting about 1 in 2500 live births, and until recently life expectancy rarely exceeded 30 years. The most common cystic fibrosis mutation (δF508, accounting for about 80% of two million British carriers), is a 3-bp deletion in a transmembrane protein cystic fibrosis transmembrane regulator gene. The next most common three or four mutations account for a further 5% of carriers.

    One in 25 white people carries cystic fibrosis. As carriers are unaffected, individuals are often unaware until …

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