Early origin of coronary heart disease

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6992.1468 (Published 03 June 1995) Cite this as: BMJ 1995;310:1468

Maternal nutrition in early pregnancy may affect placental ratio

  1. David Howe,
  2. Timothy Wheeler
  1. Senior registrar in fetal medicine Birmingham Maternity Hospital, Birmingham B15 2TG
  2. Reader in obsterics and gynaecology Princess Anne Hospital, Southampton SO16 5YA

    EDITOR,—In their editorial discussing the early origins of coronary heart disease Nigel Paneth and Mervyn Susser emphasise the importance of further investigation of the influences on the ratio of placental to fetal weight.1 Godfrey et al have proposed that iron deficiency has a role since low maternal haemoglobin concentrations and a decrease in mean red cell volume during pregnancy are associated with an increase in the ratio.2 In contrast, Perry et al found no relation between maternal haemoglobin concentrations in early pregnancy and placental …

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