Search for HIV vaccine faces setback

BMJ 1995; 310 doi: (Published 18 March 1995) Cite this as: BMJ 1995;310:691

Researchers trying to develop a vaccine against HIV faced another setback last week. An analysis of the nucleotide sequences of more than 100 AIDS viruses showed that a surprising number—nearly a tenth—were hybrids that had resulted from genetic recombination between two different strains of HIV coinfecting the same person. For researchers it means that the virus has yet another means of generating the genetic variation that has become archetypal of this human pathogen.

Scientists from Britain and the US, who published their findings in Nature, have investigated 114 viral sequences from all eight major subtypes of HIV from around the world.

At least …

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