Authors' reply

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6980.667a (Published 11 March 1995) Cite this as: BMJ 1995;310:667
  1. Lyn March,
  2. Jennifer Schwarz,
  3. Les Irwig,
  4. Judy Simpson,
  5. Catherine Chock,
  6. Peter Brooks
  1. Research fellow Research assistant Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
  2. Associate professor NSAHS Public Health Unit and Department of Public Health, University of Sydney, NSW 2006
  3. Senior lecturer in biostatics Research assistant Department of Public Health, University of Sydney, NSW 2006
  4. Professor of medicine St Vincent's Hospital, Darlinghurst, NSW 2010

    EDITOR,—We regard n of 1 trials as a useful tool to help a patient and practitioner decide whether non-steroidal anti-inflammatory drugs offer appreciably better relief than paracetamol. Only then do we think it worth using non-steroidal anti-inflammatory drugs, given their risk of serious side effects. The conceptual bias discussed by C J Hawkey is not a bias but rather our view of sensible decision making. Nor is statistical bias an issue because the decision about treatment was made not …

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