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Short stature and diabetic nephropathy

BMJ 1995; 310 doi: (Published 04 February 1995) Cite this as: BMJ 1995;310:296
  1. P Rossing, research fellowa,
  2. L Tarnow, research fellowa,
  3. F S Nielsen, research fellowa,
  4. S Boelskifte, statisticianb,
  5. B M Brenner, Samuel A Levine professor of medicinec,
  6. H-H Parving, chief physiciana
  1. a Steno Diabetes Center, DK-2820 Gentofte, Denmark
  2. b UNI-C, Danish Computing Centre for Research and Education, DK-8200 Aarhus N, Denmark
  3. c Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
  1. Correspondence to: Dr Rossing.
  • Accepted 16 December 1994

Recent studies have suggested that low birth weight is associated with a reduced number of nephrons and hypertension in later life,1 2 both well known risk factors for renal disease. An inverse correlation between microalbuminuria and height, the latter known to vary directly with birth weight,3 has been shown in non-diabetic men.4 We investigated the association between adult height and diabetic nephropathy in a cross sectional study of a cohort of insulin dependent diabetic patients attending the Steno Diabetes Center in 1984.5

Patients, methods, and results

We selected patients according to the following criteria: age >/=18 years, a duration of diabetes >/=5 years, and age at onset of diabetes </=40 years. In all, 951 patients (500 men; mean age 40 (SD 13) years; mean age at onset 18 (10) years) were enrolled (97% of those eligible). We examined urinary albumin excretion …

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