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Diuretic effect of frusemide in patients with nephrotic syndrome: is it potentiated by intravenous albumin?

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6973.162 (Published 21 January 1995) Cite this as: BMJ 1995;310:162
  1. Fehmi Akcicek, assistant professora,
  2. Turkay Yalniz, medical studenta,
  3. Ali Basci, head of renal departmenta,
  4. Ercan Ok, postdoctoral fellow in nephrologya,
  5. Evert J Dorhout Mees, professor of nephrologya
  1. a Ege University School of Medicine, Department of Internal Medicine, Division of Nephrology, Bornova 35100, Izmir, Turkey
  1. Correspondence to: Dr Akcicek.
  • Accepted 25 November 1994

We investigated the claim that infusion of albumin potentiates the diuretic effect of frusemide in patients with the nephrotic syndrome.1

Patients and methods

We selected 12 inpatients with the nephrotic syndrome according to two criteria: (a) failure to lose weight after bed rest and a 40 mmol sodium diet and (b) presence of minimal lesions or a well preserved glomerular histology on renal biopsy. We gave each patient three treatments randomly from 8 am to noon, at intervals of at least two days—infusion of albumin 0.5 g/kg given as a 20% solution for four hours; infusion of frusemide 60 mg bolus followed by 40 mg/h for four hours; and a combined treatment of both types of infusion. We collected urine on the treatment days from 8 am to 2 pm and …

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