Fortnightly Review: Bone marrow transplantationBMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6971.31 (Published 07 January 1995) Cite this as: BMJ 1995;310:31
- Correspondence to: Dr Soutar.
Bone marrow transplantation is becoming an increasingly used medical intervention
Allogeneic bone marrow transplantation remains a risky medicalprocedure, with mortality about 30%, primarily from graft versus hostdisease and infection; autologous trans- plantation has a more acceptable mortality risk of 5–10%
If results of ongoing trials in solid tumours are favourable autologous bone marrow trans- plantation may become a very common form of medical treatment
Stem cells collected from peripheral blood are increasingly being used in place of conventional autologous transplantation; they lead to more rapid engraftment, reduce duration of hospitalisation, and may help to control costs
As patient numbers increase, general practi- tioners will increasingly be confronted with the long term complications of bone marrow trans- plantation, such as infertility, secondary neo- plasms, and endocrine dysfunction
Although most survivors of bone marrow transplantation do well after transplant, 25–50% of patients will have sexual, employment, and psychosocial problems