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Amniotic band sequence in child of thalidomide victim

BMJ 1994; 309 doi: (Published 26 November 1994) Cite this as: BMJ 1994;309:1442
  1. R Tenconi,
  2. M Clementi,
  3. L Notari,
  4. V R Lo Vasco
  1. Professor of medical genetics, Academic research assistant, Resident in paediatrics, Resident in medical genetics, Servizio di Genetica Medica, Dipartimento di Pediatria, University of Padua, 35128 Padua, Italy.

    EDITOR,—Andrew P Read1 and Richard W Smithells2 dismiss W G McBride's hypothesis that thalidomide might be a mutagen.3 After this correspondence was published we saw a child with limb reduction defects born to a thalidomide victim.

    The baby had the following isolated anomalies of the left hand: almost complete absence of the third and fourth fingers, with necrotic tissue attached to the tip, while the second finger had a deep constriction ring at the proximal phalanx with a hypertrophic distal segment and hypoplastic nail. Annular constriction was also present between the first and second phalanxes of the thumb and was associated with a fibrous remnant; the fifth finger was …

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