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Triglyceride concentration and coronary heart disease High concentrations need treatment

BMJ 1994; 309 doi: (Published 10 September 1994) Cite this as: BMJ 1994;309:668
  1. A M Cruickshank
  1. Department of Biochemistry, Southern General Hospital NHS Trust, Glasgow G51 4TF
  2. Directorate of Medicine, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire AL7 4HQ.

    EDITOR, - Alan M Garber and Andrew L Avins state that use of the triglyceride concentration to guide lipid lowering treatment “must still be seen as experimental.”1 I suggest that measurement of fasting plasma triglyceride concentrations should be mandatory in any patient with hypercholesterolaemia, particularly if lipid lowering treatment (either diet or drugs) is contemplated. The type of diet or drug to which a patient responds best depends on the relative amounts of circulating cholesterol and triglyceride. Moreover, patients with very high triglyceride concentrations (almost all of whom will have hypercholesterolaemia) should be identified and treated appropriately. They are at risk of pancreatitis, and neither the hypercholesterolaemia nor the hypertriglyceridaemia is likely to respond to …

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