Hazards of reducing cholesterol

BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6953.541 (Published 20 August 1994) Cite this as: BMJ 1994;309:541
  1. C Lines
  1. Merck, Sharp and Dohme Neuroscience Research Centre, Harlow, Essex CM20 2QR.

    EDITOR, - The paper by Law and colleagues1 has given rise to further debate on the safety of cholesterol reduction. In particular, there has been speculation concerning a disputed increase in deaths from suicide and accidents,2 which might indicate detrimental effects on the central nervous system associated with lowering cholesterol.

    Data gathered during the 8245 patient, 48 week, double blind, placebo controlled, parallel groups, expanded clinical evaluation of lovastatin (EXCEL) study are pertinent …

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