Intended for healthcare professionals

General Practice

Cancer Prevention in Primary Care: Current trends and some prospects for the future - II

BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6953.517 (Published 20 August 1994) Cite this as: BMJ 1994;309:517
  1. J Austoker
  1. Cancer Research Campaign Primary Care Education Research Group, Department of Public Health and Primary Care, University of Oxford, Oxford OX2 6PE.

    Cancer control encompasses the whole spectrum from prevention and early diagnosis to treatment and palliation. The key to the future of cancer control will be to establish multidisciplinary approaches to each type of cancer across this spectrum. For primary prevention this requires some understanding of the causes of each cancer. Although understanding of the aetiology of cancer has greatly improved, prospects for the primary prevention of many common cancers remain remote. Other approaches currently under evaluation include chemoprevention and the use of biomarkers (discussed last week). The identification of predisposing genes for some of the common cancers may have a considerable impact on the ability to recognise those at risk. Overall, however, mortality trends indicate that reduction of smoking remains the main priority for cancer prevention in the United Kingdom. For primary care teams, brief interventions to reduce smoking are likely to achieve the greatest benefit. This should be seen as part of broader policies aimed at achieving change in the whole population. The government must acknowledge its major responsibility to cancer prevention by banning all forms of advertising and promotion of tobacco.

    Genetic basis of cancer: prospects for prevention

    Cancer is essentially a genetic disease at the cellular level. It is caused by abnormalities in the genetic mechanisms which control cellular growth and proliferation. Most gene alterations associated with cancer are acquired through exposure to environmental carcinogens such as certain chemicals, radiation, infectious organisms, or factors in the diet. Only a small minority are inherited in the germline. Almost all cancers in humans have both sporadic and genetic counterparts. Genetic alterations may indirectly increase the risk of mutations occurring in growth related genes by affecting the metabolism of an environmental carcinogen or DNA repair mechanisms. Genetic predisposition to cancer may also result from inherited mutations in genes that are directly concerned with normal growth and differentiation. …

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