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Alzheimer Disease, Down Syndrome and their Relationship

BMJ 1994; 309 doi: (Published 06 August 1994) Cite this as: BMJ 1994;309:418
  1. F J Dunne

    The first detailed description of Down's syndrome is attributed to the English physician John Langdon Down in 1886. In 1907 the German neuropathologist Alois Alzheimer published a report of progressive intellectual, deterioration in a middle aged patient, and a subsequent necropsy identified the presence of plaques and intensely staining fibrils. The term Alzheimer's disease was subsequently applied by Kraepelin (1910) to describe a presenile dementia characterised by what were then believed to be unique histopathological findings.

    It was not until 1948 that George A Jervis first recognised a genuine association between Alzheimer's disease and Down's syndrome. However, his findings languished in relative …

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