BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6948.212 (Published 16 July 1994) Cite this as: BMJ 1994;309:212

Adenocarcinoma of the oesophagus has tripled in incidence in the United States since 1976 (Science 1994;264:1847-8). The cause seems to be the development of Barrett's oesophagus secondary to chronic reflux, but why this should have become so much more common is unclear. Suspects include the nitrosamines in hot dogs and two classes of drugs - H2 receptor antagonists and calcium channel blockers.

When doxorubicin is given in the morning the fall in the white cell count is less and recovery is quicker than when it is given in the afternoon. Optimum timing of the doses of doxorubicin and cisplatin improves five year survival of patients with ovarian cancer by a factor of four, says a review of the effects of time on chemotherapy in “The Sciences” (1994;34:32-7). Optimum timing may tip the balance between effectiveness and side effects for drugs across the whole range of clinical medicine.

A massive study in Norway has shown that women whose first child had a birth defect were several times as likely as other women to have a second child with …

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