Papers
Drug Points: Pustular eruptions after chlorpromazine
BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6947.97a (Published 09 July 1994) Cite this as: BMJ 1994;309:97
- N P Burrows,
- R C Ratnavel,
- P G Norris
- (Department of Dermatology, Addenbrooke's NHS Trust, Cambridge CB2 2QQ).
We report on two patients who developed pustular eruptions after treatment with chlorpromazine.
A 32 year old white man with the Eaton-Lambert syndrome and a longstanding history of obsessive compulsive disorder with unipolar depression was prescribed chlorpromazine (250 mg daily) for an acute psychotic episode. The dose was increased to 700 mg over the next 10 days. Three weeks later he developed a fever (38.5°C) and a macular eruption on his trunk, which was itchy and erythematous. The rash spread to his limbs and …