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Trails of antiplatelet therapy

BMJ 1994; 308 doi: (Published 21 May 1994) Cite this as: BMJ 1994;308:1371
  1. H Bounameaux
  1. Division of Angiology and Haemostasis, University Hospital Geneva, Switzerland
  2. Clinical Trial service Unit and ICRF Cancer Studies Unit Radclife infirmary, Oxford OX2 6HE
  3. Department of Neurology, Western General Hospital Edinburgh EH4 2XU.

    Editor, - The impressive collaborative overview of antiplatelet therapy for prevention of venous thromboembolism1 raises several question which are of great practical relevance in daily practice. Firstly, this meta -analysis contradicts the recommendations given by consensus panels2 and also the general opinion of experts that aspirin has little or no effect on venous thrombosis or pulmonary embolism. Secondly, the authors studied 9000 randomised patients from 62 trials (only two published later than 1985); another systematic overview published five years ago found only five trials and 762 randomised patient and concluded …

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