Reye's syndrome

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6933.919b (Published 02 April 1994) Cite this as: BMJ 1994;308:919
  1. M Casteels-van Daele,
  2. E Eggermont
  1. Department of Paediatrics, University Hospital Gasthuisberg, University of Leuven, 3000 Leuven, Belgium.

    EDITOR, - We agree with John F T Glasgow and Raymond Moore that Reye's syndrome is a heterogeneous disorder.1 Indeed, it is a non- specific clinicopathological entity, the microvesicular lipid accumulations evident in the liver on light microscopy now being considered to be a non- specific finding for which there are many other causes.1,2 Electron microscopy is now recommended, but in the epidemiological studies reported it has been done in relatively few cases. With regard to aetiology, it is clear that the diagnosis of Reye's syndrome has been revised recently in favour of an inherited metabolic disorder in many patients; other patients are nowadays more correctly diagnosed as having viral …

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