Genetic susceptibility to non-insulin dependent diabetes

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6927.534a (Published 19 February 1994) Cite this as: BMJ 1994;308:534
  1. L Groop,
  2. G F Bottazzo
  1. Department of Endocrinology, University of Lund, Malmo General Hospital, S-214 01 Malmo, Sweden
  2. Department of Immunology, London Hospital Medical College, London E1 2AD.

    EDITOR, - Eva Tuomilehto-Wolf and coworkers have presented the interesting hypothesis that genetic susceptibility to non-insulin dependent diabetes mellitus is located in the HLA region. Their conclusions are based on findings in 157 elderly Finnish men (age 70-89), in whom HLA haplotypes associated with insulin dependent diabetes could explain 98% of non-insulin dependent diabetes and 79% of impaired glucose tolerance. This association depended strongly …

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