Genetic markers in alcoholic liver disease

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6924.341b (Published 29 January 1994) Cite this as: BMJ 1994;308:341
  1. J Alcolado
  1. Department of Medicine, University Hospital of Wales, Cardiff CF4 4XN.

    EDITOR, - D I N Sherman and colleagues suggest that variation in the alcohol dehydrogenase 2 gene may contribute to alcoholic liver disease.1 Their study, however, has several shortcomings and their conclusions may be unjustified.

    The initial hypothesis is unclear. The authors confuse genetic susceptibility to misuse of alcohol and genetic susceptibility to alcoholic liver disease; it is unlikely that the same genes contribute to these different disorders. …

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