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Scientists grow sperm from germ cells

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6922.156 (Published 15 January 1994) Cite this as: BMJ 1994;308:156
  1. A Dorozynski

    For the first time researchers have succeeded in culturing male germ cells in vitro and bringing them through meiosis to become mature sperm. The trick was achieved by culturing immature germ cells from mice with Sertoli cells. Sertoli cells are essential to support and nourish the immature germ cells, but previous attempts at coculturing germ and Sertoli cells have failed because cultured Sertoli cells rapidly degenerate and disappear.

    The team of researchers, headed by Francois …

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