Consider prophylaxis in systemic lupus erythematosus

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6921.133c (Published 08 January 1994) Cite this as: BMJ 1994;308:133
  1. K A Davies,
  2. H L C Beynon,
  3. M J Walport
  1. Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN.

    EDITOR, - Mary McMullin and George Johnston advocate lifelong prophylaxis with penicillin for patients after splenectomy.1 We believe that a similar approach should be considered for patients with impaired splenic function because of systemic lupus erythematosus, particularly in association with hypocomplementaemia.

    After surgical splenectomy, patients are at risk of developing overwhelming bacteraemia because of their failure to clear certain organisms from the …

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