Intended for healthcare professionals

Research Article

Relation of bronchioloalveolar carcinoma to tobacco.

British Medical Journal 1992; 304 doi: (Published 29 February 1992) Cite this as: British Medical Journal 1992;304:541
  1. A. Morabia,
  2. E. L. Wynder
  1. American Health Foundation, New York, NY 10017.


    OBJECTIVE--To determine whether bronchioalveolar carcinoma is related to tobacco use. DESIGN--Case-control study. SETTING--11 teaching hospitals of Chicago, Long Island, New York, and Philadelphia, 1977-89. SUBJECTS--87 patients with histologically diagnosed bronchioloalveolar carcinoma (cases) and 286 non-cancer and 297 cancer patients matched to cases on age, sex, race, hospital, and date of admission. RESULTS--10% of male cases and 25% of female cases had never smoked. Relative risks of bronchioloalveolar carcinoma (as estimated by the relative odds) were greater for subjects who started smoking at a younger age, smoked for a longer time, or smoked more cigarettes per day. Relative risks decreased proportionally to the duration of smoking cessation. CONCLUSION--Smoking plays an important part in the aetiology of bronchioloalveolar carcinoma but is not the only potential cause because of the large proportion of never smokers among patients with this disease.