Research Article

An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea.

Br Med J 1975; 3 doi: (Published 02 August 1975) Cite this as: Br Med J 1975;3:274
  1. M R Glass,
  2. R W Shaw,
  3. W R Butt,
  4. R L Edwards,
  5. D R London


    Fourteen patients with amenorrhoea and hyperprolactin-anemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to explain the menstrual disturbances in subjects with hyperprolactinaemia.