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Histocompatibility Antigens in Active Chronic Hepatitis and Primary Biliary Cirrhosis

Br Med J 1974; 3 doi: (Published 07 September 1974) Cite this as: Br Med J 1974;3:604
  1. R. M. Galbraith,
  2. A. L. W. F. Eddleston,
  3. M. G. M. Smith,
  4. Roger Williams,
  5. R. N. M. McSween,
  6. G. Watkinson,
  7. Heather Dick,
  8. L. A. Kennedy,
  9. J. R. Batchelor


    The frequency of antigens HL-A 1 (48%) and HL-A 8 (52%) in 54 patients with active chronic hepatitis from south-east England was significantly higher than in 89 control subjects from the same region (22% and 17% respectively). No correlation could be detected with the age and sex of the patients or with the presence of a particular immunological abnormality but the frequency of HL-A 1 and HL-A 8 was much lower in the nine patients who were positive for HBAg than in the 45 HBAg-negative cases. These results provide further evidence of the importance of genetic factors in active chronic hepatitis. In contrast the frequency of HL-A 1 and HL-A 8 in primary biliary cirrhosis, both in 45 patients from south-east England and in 28 patients from western Scotland, was not significantly different from that found in control groups from the same regions.