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Assessment of Deoxyuridine Suppression Test in Diagnosis of Vitamin B12 or Folate Deficiency

Br Med J 1974; 3 doi: (Published 20 July 1974) Cite this as: Br Med J 1974;3:148
  1. S. N. Wickramasinghe,
  2. J. E. Longland


    Deoxyuridine (dU) suppression tests have been performed on virtually all marrow samples aspirated at this hospital over the past 12 months. Of the 110 samples studied 26 gave abnormal results, and these 26 samples came from patients deficient in either vitamin B12 or folate. The dU suppression test was found to be of particular value in the diagnosis of vitamin B12 or folate deficiency in non-anaemic patients with macrocytosis and equivocal changes in marrow morphology and in patients in whom the serum vitamin B12 or red cell folate levels were within the normal range.