Papers And Originals

Effect of Prolonged Thiazide Treatment on Renal Lithium Clearance

Br Med J 1974; 3 doi: (Published 20 July 1974) Cite this as: Br Med J 1974;3:143
  1. V. Petersen,
  2. S. Hvidt,
  3. K. Thomsen,
  4. M. Schou


    Renal lithium clearances were determined after the administration of a small test dose of lithium carbonate in 22 patients when they were on long-term treatment with thiazides and when they were not on such treatment. Thiazide administration led to a 24% reduction in the lithium clearance. Diuretic drugs should be used with caution in patients given lithium treatment, and lithium should be used with caution in patients receiving diuretic treatment.