Papers And Originals

Immunological Studies on the Mechanism of Gold Hypersensitivity Reactions

Br Med J 1973; 3 doi: (Published 29 September 1973) Cite this as: Br Med J 1973;3:676
  1. P. Davis,
  2. A. Ezeoke,
  3. Janet Munro,
  4. J. R. Hobbs,
  5. G. R. V. Hughes


    Immunological studies were performed on 12 patients with rheumatoid arthritis who developed reactions to gold. IgE levels were found to be raised in 10 of 11 patients tested at the time of the gold reaction, returning to normal on stopping therapy. Two of 12 patients with gold reactions had positive in-vitro lymphocyte transformation responses to gold.

    It is suggested that dermatological side effects in particular are mediated by a type I hypersensitivity response.