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Effect on Neonatal Jaundice of Oestrogens and Progestogens Taken before and after Conception

Br Med J 1973; 3 doi: (Published 22 September 1973) Cite this as: Br Med J 1973;3:605
  1. J. B. McConnell,
  2. J. F. T. Glasgow,
  3. R. McNair


    Study of 182 newborn babies has shown that among bottle-fed infants the mean plasma bilirubin concentration was slightly but significantly higher (P <0·01) in those whose mothers had previously used steroid contraceptives. A similar finding was not noted among breast-fed infants.

    A further 16 infants whose mothers had received progestogen therapy during their pregnancy had a mean plasma bilirubin concentration which was significantly higher than each of the four other groups of infants studied (P <0·01). Icterus occasionally reached clinically important levels in these babies.