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Benzodiazepines and Tricyclic Antidepressant Plasma Levels

Br Med J 1973; 3 doi: (Published 07 July 1973) Cite this as: Br Med J 1973;3:18
  1. Gerald Silverman,
  2. R. A. Braithwaite


    Twelve patients acted successfully as subjects to study what effect if any the benzodiazepines nitrazepam, diazepam, oxazepam, and chlordiazepoxide might have on steady-state plasma levels of nortriptyline and amitriptyline. No significant detectable effect was discovered. In view of the known interaction effects of other alternative tranquillizing drugs and hypnotics it seems reasonable to choose benzodiazepines wherever possible when anxiolytics or hypnotics need to be added during treatment of depression with tricyclic antidepressants.