Papers And Originals

Effect of Synthetic Luteinizing Hormone Releasing Hormone (LH FSH-RH) in Women with Menstrual Disorders

Br Med J 1972; 3 doi: (Published 29 July 1972) Cite this as: Br Med J 1972;3:271
  1. John Newton,
  2. William P. Collins


    Synthetic luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) (50 μg) was given intravenously to six women with oligomenorrhoea and to four women with secondary amenorrhoea. Peripheral venous blood was withdrawn at regular intervals over a 24-hour period. The concentrations of LH, FSH, and oestradiol-17β were determined by radioimmunoassay. In all subjects there was a variable rise in LH (3-16 times the mean basal level): in six a small rise in FSH (two to three times the mean basal level) and in seven a twofold to threefold rise in oestradiol three to eight hours after the rise in gonadotrophins.