Papers And Originals

Autonomic Disturbance at Onset of Acute Myocardial Infarction

Br Med J 1972; 3 doi: (Published 08 July 1972) Cite this as: Br Med J 1972;3:89
  1. S. W. Webb,
  2. A. A. J. Adgey,
  3. J. F. Pantridge


    Of 74 patients seen within 30 minutes of the onset of acute myocardial infarction 68 (92%) had signs of autonomic imbalance. Excessive vagal activity was evident in 41 (55%) and there was sympathetic overactivity in 27 (36%). The high incidence of sudden death in the acute phase of a coronary attack probably results from the electrical imbalance caused by autonomic disturbance. This disturbance must therefore be taken into account in any prophylactic regimen against the lethal early ventricular dysrhythmias.