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Papers And Originals

Idiopathic Parkinsonism Treated with an Extracerebral Decarboxylase Inhibitor in Combination with Levodopa

Br Med J 1971; 3 doi: (Published 25 September 1971) Cite this as: Br Med J 1971;3:729
  1. D. B. Calne,
  2. J. L. Reid,
  3. S. D. Vakil,
  4. Sumant Rao,
  5. A. Petrie,
  6. C. A. Pallis,
  7. J. Gawler,
  8. P. K. Thomas,
  9. A. Hilson


    The clinical actions of levodopa in Parkinsonism, given with and without an extracerebral decarboxylase in hibitor, L-alpha-methyldopahydrazine, were compared. Twenty-one patients were investigated in a “double-blind cross-over” study, administering levodopa in maximum tolerated dosage. L-Alpha-methyldopahydrazine failed to augment the overall therapeutic actions of levodopa but it consistently alleviated nausea. It is concluded that L-alpha-methyldopahydrazine will prove useful in the management of some Parkinsonian patients who have difficulty in taking levodopa alone.